Obesity Correction: Activate Brown Fat
Why prescribing a very effective drug is not enough.
A new cure (?!?), for obesity!
This just in, from Medscape medical news: an excellent article, entitled “Experts Aim to Use Brown Fat to Burn Fat More Effectively”, by Ute Eppinger, on March 29, 2024.
This is a very good article, which you may wish to read (click the link above). It claims that (more or less) all you need to do for obesity is to activate the brown fat. It goes on to suggest the use of Mirabegron, which is quite safe and actually, a very good medication.
However as usual, this is a synthetic medication, prescribed without any thought as to the origin of obesity’s underlying problem and with no effect on other aberrations, apart from obesity, caused by the underlying problem: this is the usual “tack” of Allopathic medicine: treatment to eliminate symptoms, without affecting the disease.
What causes “Underactive Brown Fat”?
The cause of underactive brown fat, and therefore of obesity, is of course, a reduction in the quantity of thyroid 3 (FT3) available to it. Brown fat is activated by a combination of T3 and Noradrenaline: Noradrenaline is supplied in adequate quantity by the sympathetic nervous system; but stressed humans develop “Intracellular Hypothyroidism”, a.k.a. “Low T3 Syndrome”, in which their cells convert T4, the thyroid Hormone, into reverse T3 instead of normal T3. When that happens, There is not enough T3 in the serum and the brown fat, starved of T3, stop working.
Re. Mirabegron
Mirabegron is safe and costs less than C$2/tablet. Big Pharma would like us to prescribe it, on the basis that it stimulates brown fat and reliably causes some weight loss. However the drug, as usual, treats symptoms, not cause: it is a treatment of the end result of a pathological condition, not a treatment of the condition itself.
So Mirabegron, although effective in getting rid of the obesity, does nothing to eliminate the T3 starvation which caused the obesity by shutting off the brown fat and it does nothing to help the other symptoms associated with Low T3.
Re obesity
The cause of obesity is explained in my two posts on brown fat (1) BF & O and (2) “More, on Brown Fat”. Brown fat is activated by the combination of T3 and Noradrenaline (from the sympathetic innervation of brown fat). Noradrenaline without T3 does not activate it and T3, without noradrenaline, doesn’t activate it either.
You can get a handle on whether an obese person has the low T3 syndrome by checking the thyroid profile, including TSH, FT4, FT3 and rT3: that is explained in another post: how to diagnose intracellular hypothyroidism (a.k.a. “subclinical hypothyroidism”, “Low T3 Syndrome (LT3S)” and “nonthyroidal illness”.
So if you examine an obese person and find that he or she has a low body temperature, you should test for FT3 and rT 3 together: if the ratio between serum FT3 and reverse T3 is over 20, you will have diagnosed the low T3 syndrome.
